A Nest case-control study on the relationship between delivery mode and perinatal intestinal flora and renal damage in elderly women with preeclampsia

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2300069920

Enrollment

Unknown

Registered

2023-03-29

Start date

2023-04-01

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy with eclampsia

Interventions

Normal maternal group:Normal cesarean section without intervention

Preeclampsia group:Normal cesarean section without intervention

Preeclampsia group:Transvaginal delivery

Eligibility

Sex/Gender

Female

Age

35 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1) Age >= 35 years old 2) Pre-eclampsia group: women with ASA II to III, diagnosed as pre-eclampsia by obstetrician 3) Normal group: age-matched normal puerpera

Exclusion criteria

Exclusion criteria: 1) Multiple pregnancy 2) Pre-pregnancy diabetes, hypertension, kidney disease 3) Intestinal diseases: enteritis, Crohn's disease, etc 4) Combined with systemic lupus erythematosus and other immune system diseases, and the need for long-term glucocorticoid therapy 5) Complications of pregnancy: epilepsy, heart disorders, hematological diseases, infectious diseases, viral hepatitis, intrahepatic cholestasis syndrome of pregnancy 6) Antibiotics were used within 1 month of fecal collection 7) Depression, anxiety and other mental diseasesc

Design outcomes

Primary

Measure	Time frame
LPS;Negative rate of urinary protein;	—

Secondary

Measure	Time frame
Intestinal bacterial diversity and relative abundance of beneficial and harmful bacteria;Occluding protein;syndecan-1 protein;ET-1;TXA2;PGI2;Scr;BUN;ß 2-microglobulin;Urine protein;24-hour urine protein quantification;kim-1;IL-6;TNF-a;age;Parity;Gestational week;height;BMI before pregnancy;complication;Education level;Perinatal medication;Epidural anesthetic dose for cesarean section;Drug dose of epidural analgesia pump;systolic pressure;diastolic pressure;heart rate;Total drug dose of delivery analgesia pump;	—

Measure

Time frame

Intestinal bacterial diversity and relative abundance of beneficial and harmful bacteria;Occluding protein;syndecan-1 protein;ET-1;TXA2;PGI2;Scr;BUN;ß 2-microglobulin;Urine protein;24-hour urine protein quantification;kim-1;IL-6;TNF-a;age;Parity;Gestational week;height;BMI before pregnancy;complication;Education level;Perinatal medication;Epidural anesthetic dose for cesarean section;Drug dose of epidural analgesia pump;systolic pressure;diastolic pressure;heart rate;Total drug dose of delivery analgesia pump;

—

Countries

China

Contacts

Public ContactZhang Qinglin

Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital

Dr_lynn@ccmu.edu.cn+86 13910964953

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026