Anesthetic drug neurotoxicity
Conditions
Interventions
Sevoflurane group:Maintenance of anesthesia with sevoflurane during operation
Propofol group:Maintenance of anesthesia with propofol during operation
Sponsors
Xuzhou Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) 18 to 60 years 2) ASA grade?-? 3) Patients with indications for hepatobiliary surgery and operating time of not less than 2 hours 4) Agreed to participate in this study and signed an informed consent form
Exclusion criteria
Exclusion criteria: 1) Contraindications to the use of propofol or sevoflurane 2) Patients with severe heart, lung, kidney and other important organ diseases 3) Patients with severe infectious diseases, endocrine system diseases and blood system diseases 4) Those who have a history of smoking, alcohol and drug abuse 5) Received radiation and took antioxidants a week before operation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 8-hydroxy-2 deoxyguanosine; | — |
Secondary
| Measure | Time frame |
|---|---|
| Protein carbonyl;8-iso-prostaglandin F2a;Superoxide dismutase;hydrogen peroxide; | — |
Countries
China
Contacts
Public ContactZhu Yangzi
Xuzhou Central Hospital
Outcome results
None listed