brain injury
Conditions
Interventions
esketamine group:To apply esketamine before cardiopulmonary bypass
placebo group:To apply equal volume of normal saline during anesthesia induction and maintenance
Sponsors
Jinan Central Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Patients undergoing thoracotomy cardiac surgery due to severe valve stenosis, insufficiency, atrial septal or ventricular septal defect, and aortic dissection. (2) The preoperative coagulation test was normal (partial thromboplastin time 24-39s and international normalized ratio of thromboplastin 0.8-1.2, platelets 100-300*10^9). (3) Patients who have not received strong thrombolysis, anticoagulation and antiplatelet therapy in the past week. (4) Preoperative left ventricular ejection fraction >= 30%.
Exclusion criteria
Exclusion criteria: (1) Patients with disturbance of consciousness, stroke, or mental illness before surgery. (2) Patients who have been using psychotropic and anesthetic drugs for a long time (such as opioids, non-steroidal antipyretic, analgesic and anti-inflammatory drugs, sedatives, antidepressants), alcohol abuse patients, and patients with a history of abnormal surgery and anesthesia recovery. (3) Chronic wasting diseases such as blood diseases, severe immune disorders, and cancer. (4) Severe heart, lung, liver and kidney insufficiency. (5) Those who have been enrolled in other clinical drug experiments within three months or are allergic to the research drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum neuro-specific enolase;Serum S100b protein; | — |
Secondary
| Measure | Time frame |
|---|---|
| C-reactive protein;Interleukin-6;Cerebral oxygen saturation;Blood gas analysis;cardiac troponin I, cTnI;brain natriuretic peptide, BNP;Ramsay sedation score;Mini-mental State Examination,MMSE;SAS/SDS Self Assessment Scale; | — |
Countries
China
Contacts
Public ContactJun Xu
Jinan Central Hospital
Outcome results
None listed