Acute and chronic pain after thoracic surgery
Conditions
Interventions
The experimental group:Vitamin D2 600000iu (3ml) was injected intramuscularly before operation, once every half a month and supplemented for 3 months
The control group:normal saline(3ml) was injected intramuscularly before operation, once every half a month and supplemented for 3 months
Sponsors
The Third Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) age>= 18 years old, < 65 years old; (2) patients undergoing thoracotomy or thoracoscopic pneumonectomy under general anesthesia; (3) voluntarily participate in this study and sign informed consent
Exclusion criteria
Exclusion criteria: (1) patients with chronic pain (> 3 months) before operation; (2) unable to communicate due to coma, severe dementia, language disorder or end-stage disease before operation; (3) patients with severe disease (ASA >= grade IV), severe renal insufficiency (preoperative dialysis), severe liver insufficiency (chlid Pugh grade C), parathyroid disease, hypercalcemia (Ca2 + > 2.75 mmol / L), hyperphosphatemia (P > 1.62 mmol / L), history of gastric bypass surgery and urinary calculi; (4) patients who used analgesics, nonsteroidal drugs, vitamin D supplements and thiazides for a long time before operation; (5) patients with severe cardiovascular disease before operation; (6) participated in another trial that may affect vitamin D research; (7) patients with postoperative wound infection; (8) patients who refused to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of chronic pain 12 weeks after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dosage of opioids for intravenous analgesia within 96 hours after operation;The degree and incidence of chronic pain 6 months and 1 year after operation;Scores of sleep, anxiety and depression at 4 weeks, 8 weeks, 12 weeks, 6 months and 1 year after operation;health status score at 4 weeks, 8 weeks, 12 weeks, 6 months and 1 year after operation;Survival rate and recurrence rate within 1 year after operation; | — |
Countries
China
Contacts
Public ContactLiao Qin
The Third Xiangya Hospital of Central South University
Outcome results
None listed