linguistic developmental disorder and autism spectrum disorder
Conditions
Interventions
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: PART 1 1) Experimental group: 1.Informed consent of legal guardians; 2.Presence of high-risk factors for brain injury (including but not limited to prematurity, intrauterine distress, amniotic fluid III degree, neonatal asphyxia, neonatal sepsis, severe hyperbilirubinemia) or family history of language developmental disorders and autism spectrum or inherited metabolic disease; 3.Quiet during cerebral oxygen detection, near-infrared brain function imaging, and EEG detection; 4.Diagnosis of language developmental disorder or autism spectrum disorder; 5.Meeting the above criteria and meeting the exclusion criteria described below, the first 30 children diagnosed were enrolled in the experimental group according to chronological order. 2) Control group 1: 1-3. same as the experimental group; 4. Exclusion of language developmental disorders or autism spectrum disorders; 5. Eligible for the above criteria and meeting the exclusion criteria described below, the first 30 children with an exclusion diagnosis were admitted to control group 1 chronologically. 3) Control group 2: 1. Informed consent of legal guardians; 2. absence of risk factors for brain injury (including but not limited to prematurity, intrauterine distress, amniotic fluid III degree, neonatal asphyxia, neonatal sepsis, severe hyperbilirubinemia); 3. No family history of language developmental disorders and autism spectrum, no family history of inherited metabolic diseases; 4. Quiet during cerebral oxygen detection, near-infrared brain function imaging, and EEG detection; 5 Meeting the above criteria and meeting the exclusion criteria described below, the first 30 children with an exclusion diagnosis were enrolled in control group 2 chronologically. PART 2 1 Informed consent of the legal guardian; 2 Exist of the family history of high-risk factors for brain injury (including but not limited to prematurity, intrauterine distress, amniotic fluid III degree, neonatal asphyxia, neonatal sepsis, severe hyperbilirubinemia) or language developmental disorders and autism spectrum diseases or inherited metabolic diseases; 3 Keep quiet during cerebral oxygen detection, near-infrared brain function imaging, and EEG detection;
Exclusion criteria
Exclusion criteria: PART 1 1) Case group and control group 1: 1. Time to survive for all causes< 3 years; 2. social factors abandon treatment; 3. Application of sedative drugs within 48 hours before enrollment affects test results; 4. Hearing screening failed; 5. Children with predisposition to disease up to 3 years of age who cannot definitively exclude or diagnose language developmental disorders or autism spectrum disorders. 2) Control group 2: 1. Survival time < 3 years of age for various reasons, or growing neurologically-related diseases with no onset in the neonatal period; 2. social factors abandon treatment; 3. Application of sedative drugs within 48 hours before enrollment affects test results; 4. Hearing screening failed; 5. Children with predisposition to disease up to 3 years of age who cannot exclude or identify disorders of language development or autism spectrum disorders. PART 2 1 Died before < 3 years of age for any reason; 2 Discontinuation of treatment for social factors; 3 Application of sedative drugs may affect test results within 48 hours before enrollment ; 4 Failed the hearing screening.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain response characteristics of speech;Brain response characteristics of phonology;Sensitivity;specificity; | — |
Countries
China
Contacts
Public ContactXinlin Hou
Peking University First Hospital
Outcome results
None listed