Cerebral Small Vessel Disease
Conditions
Interventions
Test group :pentoxifylline sustained-release tablets
Control group:Recommended drugs in the Chinese Guidelines for Diagnosis and Treatment of Cognitive Disorders Related to Cerebrovascular Diseases, 2019
Sponsors
Nanjing Drum Tower hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: ( 1 ) Over 60 years old, regardless of gender ; ( 2 ) Clinically diagnosed as cerebral small vessel disease, there are white matter high signal ( Fazekas score 2 points and above ), and cognitive impairment ( MOCA illiteracy = 13 points, 1-6 years of education = 19 points, 7 years or more = 25 points ) ; ( 3 ) The patient himself or his legal representative signed informed consent.
Exclusion criteria
Exclusion criteria: ( 1 ) bleeding tendency : extensive retinal hemorrhage, intracranial hemorrhagic diseases ( such as hemorrhagic stroke, epidural hematoma, subarachnoid hemorrhage, etc. ), brain tumors, tumor stroke, long-term use of anticoagulant drugs ; ( 2 ) Has a clear history of cognitive impairment caused by other reasons, such as ischemic stroke, normal intracranial pressure hydrocephalus, Alzheimer 's disease, Parkinson 's disease, multiple sclerosis, encephalitis, etc. ; ( 3 ) patients with acute myocardial infarction and severe coronary atherosclerosis ; ( 4 ) severe liver dysfunction, renal insufficiency or severe cardiac insufficiency ; ( 5 ) Persons known to be allergic to pentoxifylline and methylxanthines ( such as caffeine, aminophylline, dihydroxypropyl theophylline, etc. ) ; ( 6 ) Other life-threatening or serious diseases, expected survival time < 36 months ; ( 7 ) Researchers believe that the subjects have potential risks or any other factors that interfere with the subjects, and are not suitable for participants in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| FLAIR; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination,MMSE;Montreal Cognitive Assessment, MoCA;digital span test, DST;trail making test, TMT-B;Activity of Daily Living, ADL; | — |
Countries
China
Contacts
Public ContactXu yun
Nanjing Drum Tower hospital
Outcome results
None listed