Malignant tumor, oral mucositis
Conditions
Interventions
Treatment Group:Iron sheet maple bucket particles
Control group:Sodium bicarbonate liquid
Sponsors
Shanghai Traditional Chinese Medicine-Integrated Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: ? Meet the relevant diagnostic criteria of oral mucositis and the history of anti-tumor therapy; ? No analgesic drugs or vitamin preparations were used after onset; No antibiotics were used within 3 days prior to onset of illness. ? KPS score =80, no significant damage of liver and kidney function after chemotherapy (ALT<100U/L, AST<80U/L). (4) Informed consent to participate in the study.
Exclusion criteria
Exclusion criteria: ? Patients with Behcet's disease, recurrent necrotizing mucositis, herpetic stomatitis and other diseases that have been proven to cause erythema and/or ulceration of the oral mucosa, or oral mucositis caused by other causes other than chemotherapy; ? Usually have bad alcohol and tobacco addicts; ? Have mental illness, or have intellectual disabilities, their own judgment of pain intensity difficulty.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean ulcer stage;Pain score;Grade of oral mucositis; | — |
Secondary
| Measure | Time frame |
|---|---|
| T cell subpopulation;Inflammatory cytokines;Oral saliva sIgA, human ß-defensin 2 (HßD-2);Oral short-chain fatty acid producing bacteria and oral flora (Streptococcus, Veronella, Neisseria); | — |
Countries
China
Contacts
Public ContactYi Zhong
Department of Oncology, Shanghai Traditional Chinese Medicine-Integrated Hospital
Outcome results
None listed