gastroesophageal reflux disease
Conditions
Interventions
A regimen:vonoprazan 20mg p.o. before or after breakfast
B regimen:vonoprazan 20mg p.o. before or after dinner
C regimen:vonoprazan 20mg p.o. before or after breakfast, and before or after dinner
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1)=18 years old 2)Patients having completed upper gastrointestinal endoscopy in the past one year 3)Patients with typical symptoms for at least one month and GERD-Q=8; or patients with untypical symptoms for at least one month and erosive esophagitis grade B/C/D; 4)Adherence to the allocated regimens and the follow-up procedure
Exclusion criteria
Exclusion criteria: 1)Patients with acute peptic ulcer, previous gastric or esophageal surgery history; 3)Patients with serious diseases such as hepatic failure, renal insufficiency and cancers; 4)Pregnant and lactating women; 5)Patients with communication and coordination disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of symptom relief;The healing rate of esophageal mucosa; | — |
Secondary
| Measure | Time frame |
|---|---|
| The score of quality of life; | — |
Countries
China
Contacts
Public ContactHou Xiaohua
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed