diminished ovarian reserve
Conditions
Interventions
case series:N/A
Sponsors
Dongfang Hospital, Beijing University of Chinese Medicine
Eligibility
Sex/Gender
Female
Age
18 Years to 39 Years
Inclusion criteria
Inclusion criteria: The subjects of this study were all patients with DOR who attended the outpatient clinic of Professor Jin. According to the expert consensus on the Clinical diagnosis and treatment of impaired Ovarian Reserve, expert group on the Clinical Diagnosis and treatment of impaired Ovarian Reserve (2022, Journal of Reproductive Medicine), Expert consensus on hormone replacement therapy for premature ovarian insufficiency, Chinese Society of Obstetrics and Gynecology, Chinese Medical Association (2016, China) Chinese Journal of Obstetrics and Gynecology), Chinese Expert Consensus on the Clinical diagnosis and treatment of premature ovarian insufficiency (2017, Chinese Journal of Obstetrics and Gynecology) and the 9th edition of Obstetrics and Gynecology, a textbook for the 13th Five-Year Plan (edited by Xie Xing, Kong Beihua, Duan Tao, People's Medical Publishing House, 2018). (1) Anti-Mullerian hormone (AMH) < 1.1ng/ml (1ng/ml = 7.14pmol/L). (Recommendation Grade ?B) (2) Basal antral follicle count (AFC) : AFC of bilateral ovaries was less than 5-7. (Recommendation Grade ?B) (3) Basal FSH: basal FSH 10IU/L=FSH < 25IU/L for two consecutive menstrual cycles. (Recommendation Grade ?B) (4) Age: women over 35 years old who have been trying for pregnancy for more than 6 months but still have no successful pregnancy. (Recommended Grade IIB) (5) Clinical manifestations: decreased fertility, menstrual disorder, and related symptoms of sex hormone deficiency or fluctuation. If any two of (1) (2) (3) were met, combined with relevant clinical manifestations and age, the diagnosis of DOR could be made.
Exclusion criteria
Exclusion criteria: Sex hormone levels suggest early onset ovarian insufficiency or premature ovarian failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum anti-Mullerian hormone (AMH); | — |
Secondary
| Measure | Time frame |
|---|---|
| Six sex hormones;Number of antral follicles in both ovaries;Bilateral ovarian volume;Menstrual blood loss map PBAC score;Effective rate of TCM syndrome;The disappearance rate of individual symptoms;Patient Outcome Report (PRO) : change value of Hamilton Anxiety Scale (HAMA) score, change value of Hamilton Depression Scale (HAMD) score, Fertility Quality of Life Questionnaire (FertiQol), Pittsburgh Sleep Quality Scale;Safety indicators: vital signs, blood routine, urine routine, liver and kidney function, etc; | — |
Countries
China
Contacts
Public ContactLou Jiaoying
Dongfang Hospital, Beijing University of Chinese Medicine
Outcome results
None listed