Obesity
Conditions
Interventions
Normal Diet:Normal Diet
Ketogenic Diet:Ketogenic Diet
Test Diet:Low-carb, high-protein diet
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years old 2. Female 3. Meet the indications for bariatric surgery in the Chinese Guidelines for the Surgical Treatment of Obesity and Type 2 Diabetes (2019 Edition) and intend to undergo bariatric surgery treatment 4. Reside in Shanghai 5. Agree to undergo a 1-week normal diet washout and be randomized to different diet intervention groups 6. Understand and are willing to sign the informed consent form and cooperate with the follow-up dietary intervention, surgery and follow-up arrangements
Exclusion criteria
Exclusion criteria: 1. Contraindications to surgery exist 2. History of taking the following medications within the past month: acid suppressants, antibiotics, glucose-lowering drugs, statin lipid-lowering drugs 3. History of binge eating, very low calorie diet or restricted diet, or jet lag within the past 1 month 4. History of chronic alcohol consumption or history of alcohol consumption within the past 1 month 5. Significant change in bowel habits and characteristics within the past month 6. Previous chronic bowel disease or acute bowel disease episode within the past month 7. Any hepatobiliary or pancreatic disease other than NAFLD/NASH 8. Previous history of gastrointestinal surgery 9. Concurrent presence of other serious diseases affecting the evaluation of this study and unable to cooperate 10. Inability to understand the procedures and methods of this clinical study, refusal to participate and refusal to sign the informed consent form
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in intestinal flora species and abundance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Excess weight loss rate;DEXA body fat measurement body fat percentage and visceral fat content;Abdominal MRI liver fat content;Glycated hemoglobin; | — |
Countries
China
Contacts
Public ContactHao Wu
Huashan Hospital, Fudan University
Outcome results
None listed