olfactory dysfunction
Conditions
Interventions
Oral glucocorticoid + hyperbaric oxygen treatment group:hyperbaric oxygen treatment
Oral glucocorticoid + simulated hyperbaric oxygen treatment grou: simulated hyperbaric oxygen treatment group
Sponsors
Xijing Hospital of Air Force Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Subjects must voluntarily sign informed consent; (2) Age =18 years and =60 years; (3) Decreased or lost sense of smell in olfactory stick test, total TDI score =30; (4) Anosmia occurs within 2 weeks after the diagnosis of COVID-19 infection and lasts for at least 2 weeks, no nasal congestion, runny nose and other upper respiratory symptoms. (5) Ear, nose and throat specialized physical examination, nasal endoscopy, sinus CT and cranial MR did not show sinus and cranial lesions
Exclusion criteria
Exclusion criteria: (1) Those who voluntarily asked to quit had poor compliance and could not cooperate with regular follow-up and treatment observers (2) Subjects have the following medical conditions: chronic sinusitis, asthma, eosinophilia, phantom olfactory or olfactory allergies, cystic fibrosis, congenital ciliary dyskinesia, nasal tumors, nasal facial malformations, history of nasal facial trauma resulting in nasal obstruction, invasive or non-invasive fungal sinusitis, and sinus anatomical abnormalities. (3) a severe metabolic, cardiovascular, immune, neurological, blood, digestive, cerebrovascular, or respiratory disease, accompanied by head trauma, or a disease that the investigator has assessed could affect the study results or the safety of the subject. (4) Patients with a history of craniocerebral and nasal surgery. (5) Pulmonary bullosa, eustachian tube dysfunction, severe cardiopulmonary dysfunction and other hyperbaric oxygen therapy contraindicated patients. (6) Staff members who are currently participating in other clinical studies or have participated in other clinical investigators within 30 days, or are directly involved in such studies. (7) A history of mental illness, antagonistic personality, bad motivation, paranoia, or other emotional or intellectual problems may affect the informed validity of participants in the study. (8) Pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SNOT-22;Visual Analogue Scale;Sniffin' Sticks olfactory test (TDI) score; | — |
Countries
China
Contacts
Public ContactFuquan Chen
First Affiliated Hospital of Air Force Medical University
Outcome results
None listed