Thyroid cancer
Conditions
Interventions
Esketamine hydrochloride induced plus maintenance group:Esketamine hydrochloride 0.2mg/kg combined with sufentanil 0.2ug/kg in the induction period, and Esketamine hydrochloride 0.5mg/kg/h in the main
Esketamine hydrochloride maintenance group:Sufentanil 0.4ug/kg in induction period and Esketamine hydrochloride 0.5mg/kg in maintenance period
Traditional anesthesia group:Sufentanil 0.4ug/kg during induction and remifentanil (0.15-0.25)ug/kg/min during maintenance. Esketamine was not used
Sponsors
First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. General anesthesia for daytime thyroid cancer is proposed, ASA grade I-II 2. Age 18-65 3.BMI 18-30Kg/M2 4. Communication is normal 5. Volunteers and sign informed consent
Exclusion criteria
Exclusion criteria: 1.Unstable angina or myocardial infarction in the past six months, or a history of prior severe angina 2.Congestive heart failure 3.Elevated intracranial pressure and central nervous system damage 4.Have or have had a history of serious mental disorders 5.Increased intraocular pressure, glaucoma 6.Inability to understand visual analogue scale (VAS) 7.Inability to understand 15-item Quality of Recovery (QoR-15) 8. Inability to understand the Hospital Anxiety and Depression Scale (HADS) 9. Inability to understand the modified Brice questionnaire and Likert scale
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Opioid use;Postoperative nausea and vomiting;Postoperative recovery quality scale 15 items;Hospital Anxiety and Depression Scale;Improved Brice questionnaire and Likert scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ramsay sedation score;visual analogue scale;Postoperative ventilation time;blood sugar monitoring;Happiness and Satisfaction Survey; | — |
Countries
China
Contacts
Public ContactChen Jingjing
First Affiliated Hospital of Anhui Medical University
Outcome results
None listed