Cognitive Impairment
Conditions
Interventions
Without cognitive impairment group:N/A
Sponsors
The People's Hospital of Bao'an, Shenzhen
Eligibility
Sex/Gender
Female
Age
40 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Perimenopausal women without cognitive impairment. (1) Meets diagnostic criteria for perimenopause. (2) Aged between of 40-60 years. (4) SCD-Q9 score <5. (5) MoCA score of =26; (1 point added to the score if =12 years of education) (6) Right-handedness. (7) Signed informed consent and voluntary participation. 2. SCD perimenopausal women. (1) Meets the diagnostic criteria for SCD. (2) Meets the criteria for perimenopausal diagnosis. (3) Aged between 40-60 years. (4) SCD-Q9 score = 5. (5) MoCA score of =26; (if years of education =12, add 1 point to the score) (6) Right-handedness. (7) Signed informed consent and voluntary participation. 3. MCI perimenopausal women. (1) Meeting the diagnostic criteria for MCI (2) Meeting the diagnostic criteria for perimenopause. (3) Ages between 40-60 years of age (4) MoCA score between 18-25; (1 point will be added to the score if the number of years of education is =12 years) (5) Right-handedness. (6) Signed informed consent form and voluntary participation.
Exclusion criteria
Exclusion criteria: (1) Have a history of psychiatric disorders. (2) have a history of neurological disorders (3) A history of alcohol or drug abuse (4) surgical menopause (history of hysterectomy and bilateral adnexal resection) (5) Reproductive tumours and vaginal bleeding of unknown origin. (6) Hormonal drugs taken in the last 3 months prior to study participation. (7) Those who are unable to complete the index assessment, such as severe aphasia, visual and hearing impairment, illiteracy, etc. (8) Those who are participating in other research trials that affect the results of this study. (9) Not signing informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxyhemoglobin concentration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Subjective Perception Decline Questionnaire;MoCA;Digital span test;Menopause assessment;Depression Screening Scale;Anxiety Self-Assessment Scale;Sleep Quality Index;working memory;Activities of daily living; | — |
Countries
China
Contacts
Public ContactChen Shangjie
The People's Hospital of Bao'an, Shenzhen
Outcome results
None listed