lung tumor
Conditions
Interventions
experimental group 1:Intravenous lidocaine was induced at 1.5mg/kg
experimental group 2:Tracheal lidocaine 3.0mg/kg spray
Sponsors
Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College
Eligibility
Sex/Gender
All
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: ?ASA ? - ?, age 30-65; ? Body mass index (BMI) 20kg/m2=BMI=25kg/m2; ?Mallampati airway grade ? or ?; ?No myasthenia gravis, hypertension and difficult airway, no drugs affecting blood pressure and heart rate; ?Be able to read and understand the content of informed consent and sign the informed consent.
Exclusion criteria
Exclusion criteria: ? Patients with lidocaine and other drug allergy history; ? Patients with a history of cerebrovascular disease or epilepsy; ? Patients treated with calcium channel blockers; ? Long-term use of cimetidine, ß -blockers and other drugs affecting lidocaine metabolism; ? Patients with asthma history; ? Patients whose endotracheal intubation time exceeds 30 seconds or whose first intubation fails; ? Patients with severe liver and kidney diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood concentration of lidocaine;Pharmacokinetic parameters of lidocaine; | — |
Secondary
| Measure | Time frame |
|---|---|
| ntraoperative blood loss, intraoperative crystalline or colloidal infusion volume;Preoperative hemoglobin;Liver function of the patients;renal function of patients;age;height;gender;body mass index;ASA class;coagulation function; | — |
Countries
China
Contacts
Public ContactTu Faping
Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College
Outcome results
None listed