Alzheimer's disease
Conditions
Interventions
Alzheimer’s disease:A Novel Synaptic Density Tracer 18F-SDM-8
Elderly health volunteers:A Novel Synaptic Density Tracer 18F-SDM-8
Sponsors
Department of Nuclear Medicine, The First Medical Centre, Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: With reference to Petersen and other diagnostic criteria for AD patients, the inclusion criteria of AD subjects included: 1) the subjects or their family members complained of obvious memory impairment; 2) Objective memory impairment (such as object memorization, recall, delayed memory, etc.); 3) CDR=1.0; 4) MMSE 11-23 points; 5) Meet DSM IV and NINCDS-ADRDA criteria for Alzheimer's disease dementia. Healthy control group included: 1) overall health status; 2) There are no complaints of memory impairment. Cognitive function was normal by the combined screening of MMSE (28-30 points) and MoCA (26-30 points).
Exclusion criteria
Exclusion criteria: 1) History of stroke, HIS > 4; 2) Alcohol addiction; 3) Major mental illnesses: including anxiety disorders, emotional disorders, major psychosis, or drug-induced psychosis; 4) Neurological diseases: including brain tumors, craniocerebral trauma, multiple sclerosis, epilepsy, etc.; 5) Patients with serious medical conditions who are currently using respiratory drugs, cardiovascular drugs, anticonvulsants or psychoactive substances; 6) People with severe hearing and visual impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 18F-SDM-8-PET neuroimaging;Brain region SUV value; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reactions; | — |
Countries
China
Contacts
Public ContactRuimin Wang
Department of Nuclear Medicine, The First Medical Centre, Chinese PLA General Hospital
Outcome results
None listed