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Efficacy and safety of esketamine in relieving severe anxiety in patients before major surgery: a randomized non-inferiority study

Efficacy and safety of esketamine in relieving severe anxiety in patients before major surgery: a randomized non-inferiority study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300069728
Enrollment
Unknown
Registered
2023-03-24
Start date
2023-04-01
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preoperative anxiety

Interventions

esketamine:esketamine 0.20mg/kg 40min

Sponsors

The First Affiliated Hospital of Zhengzhou University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1) Age = 18 years old. 2) Physical condition I - II of the American Society of Anesthesiologists. 3)BMI 18-30 kg/m2 4) Plan to receive general anesthesia surgery, and the preoperative anxiety score on NRS is greater than or equal to 5/10. 5) Volunteer to participate in this study and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1)Refusal to participate. 2)Contraindications or allergic to esketamine. 3)History of chronic pain or opioid abuse before operation. 4)With psychiatric disorders (schizophrenia, mania, psychosis, etc.) or cognitive dysfunction.

Design outcomes

Primary

MeasureTime frame
Preoperative anxiety score;

Secondary

MeasureTime frame
side effects;postoperative pain;Recovery quality score;

Countries

China

Contacts

Public ContactJianjun Yang

The First Affiliated Hospital of Zhengzhou University, No.1, East Jianshe Road, Zhengzhou City, Henan Province

yjyangjj@126.com13783537619

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026