Cervical degenerative disease
Conditions
Interventions
A:Collagen biomembrane+Glucocorticoid
B:Collagen biomembrane only
C:blank
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Age 18-65; (2) According to the clinical symptoms, physical signs and imaging findings (satisfying any of the following conditions: nucleus pulposus prolapse; obvious osteophyte formation; intervertebral height loss), patients with cervical spondylosis were diagnosed clearly; (3) Those who are ineffective or have progressive symptoms after standard conservative treatment, affecting daily life and work, and need to undergo anterior decompression surgery; (4) The surgical segment is between C3/4 and C6/7. (5) Be able to fully comply with this agreement psychologically and physically, and cooperate with the scheduled treatment plan, fill in the form, and follow up. (6) After the patient signs the informed consent, it means that the patient has known and agreed to carry out the relevant aspects of this study. The above inclusion standards are international common standards to ensure rationality and feasibility.
Exclusion criteria
Exclusion criteria: (1) Previous history of cervical surgery. (2) Ossification of posterior longitudinal ligament or stenosis of cervical spinal canal, spinal fracture, severe osteoporosis or history of bone metabolic disease. (3) Local infection and ulceration of neck skin, systemic inflammatory disease, uncontrolled diabetes, malignant tumor, active hepatitis, etc. (4) People with mental illness or mental disorder. (5) The general condition is poor, and important organs are suffering from serious diseases and cannot tolerate surgery. (6) Known to suffer from infectious diseases such as AIDS, syphilis, etc. (7) Suffer from autoimmune diseases. (8) He has received daily immunosuppressive therapy for more than 1 month in the past 12 months. (9) Allergic to implant materials (PPE K or titanium alloy) or experimental drugs. (10) Severe obesity, drug abuse history. (11) Pregnancy planner during pregnancy or study. (12) He is participating in other studies that may affect the results of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Baza score;Swallowing-Quality of Life; | — |
Secondary
| Measure | Time frame |
|---|---|
| Prevertebral soft tissue thickness;fusion rate; | — |
Countries
China
Contacts
Public ContactHao Liu
West China Hospital, Sichuan University
Outcome results
None listed