sedative colonoscope
Conditions
Interventions
Group 1:Determination of median effective dose of esketamine combined with remifentanil in anesthesia induction of sedative colonoscope by sequential method
Sponsors
Anesthesiology Department of Northern Jiangsu People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Perform simple sedative colonoscope; 2. There are no contraindications for sedative colonoscope; 3. American Society of Anesthesiologists (ASA) classification I-II; 4. No neurological abnormalities or family history of mental illness; 5. All voluntarily participate and sign the informed consent; 6. Complete communication skills, normal hearing and smooth response; 7. Aged 18 to 60 years.
Exclusion criteria
Exclusion criteria: 1. Plan to perform endoscopic diagnosis and treatment techniques with complex operations or severe stimuli (such as endoscopic ultrasonography (EUS), endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD, etc.) wait); 2. Patients with heart, liver, kidney and other important organ dysfunction; 3. Patients who are pregnant or breastfeeding; 4. American Society of Anesthesiologists (ASA) classification III-V; 5. Communication barriers caused by problems such as dysphonia, hearing impairment, low education level, stroke, and Alzheimer's disease, and the inability to correctly understand the investigators' inquiries; 6. Refuse to cooperate or disagree to participate in the project.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation success rate (sedation success is defined as completing the entire colonoscopy diagnosis and treatment operation, not receiving sedation rescue drugs and other conditions that meet the sedation failure criteria; sedation success rate is the proportion of successful sedation subjects to all subjects);The target sedation depth is the deep sedation level;Sedation induction time (the time from the start of sedation induction to the start of painless colonscope diagnosis and treatment, that is, the time from the start of sedation induction to the MOAA/S score <=1);After successful induction, when the colonscope enters the endoscope, the incidence and order of severityof body movements; | — |
Secondary
| Measure | Time frame |
|---|---|
| During the diagnosis and treatment, the incidence and severity of body movement;Adverse event;Sedation recovery time (time between the last sedative administration and Aldrete >= 9);Sedation process satisfaction score; | — |
Countries
China
Contacts
Public ContactLiu Xin
Anesthesiology Department of Northern Jiangsu People's Hospital
Outcome results
None listed