birth defects
Conditions
Interventions
Birth defects (Digital PCR-NIPT technology):None
Sponsors
Obstetrics & Gynecology Hospital of Fudan University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: To ensure that the proportion of fetuses with positive fetal chromosomal trisomies is maintained, this study will be conducted on the following special groups of pregnant women. (1) Pregnant women with a serological screening result of "high risk of Down's syndrome (risk value >1/270)" or "high risk of trisomy 18 (risk value >1/350)". (2) Pregnant women of advanced age. (3) Pregnant women with NGS-NIPT screening results of "T21 high risk", "T18 high risk", or "T13 high risk".
Exclusion criteria
Exclusion criteria: (1) Pregnant women without complications such as malignancy. (2) Samples with very low concentrations of maternal peripheral blood DNA. (3) Other conditions considered by the investigator as unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| T21,T18,T13 Conformity; | — |
Secondary
| Measure | Time frame |
|---|---|
| T21,T18,T13 Sensitivity;T21,T18,T13 Specificity; | — |
Countries
China
Contacts
Public ContactXu Chenming
Obstetrics & Gynecology Hospital of Fudan University
Outcome results
None listed