Infantile eczema
Conditions
Interventions
Group 1:2 intervention once daily
Group 2:2 placebo once daily
Sponsors
Shaoguan Maternity and Child Health Care Hospital
Eligibility
Sex/Gender
All
Age
0.5 Years to 2 Years
Inclusion criteria
Inclusion criteria: 1) Infants > 36 weeks of gestational age, 6 months to 3 years of age, male or female: 2) Infant formula fed exclusively at the first six months of age and without prebiotics and probiotics at the last six months; 3) Birth weight > 2500g and = 25 as determined by Hanifin and Rajka criteria.
Exclusion criteria
Exclusion criteria: 1) Patients with diseases that seriously affect the digestion and absorption of test samples; 2) Patients who have used systemic corticosteroids within 1 month, antihistamines within 7 days or local calcineurin inhibitors within 1 month; 3) Patients who are using drugs that may affect the test effect (such as hormones, anti-tumor drugs, sedatives or other muscle relaxants, etc.); 4) Seborrheic dermatitis, contact dermatitis and other skin diseases; 5) Patients with diarrhea, fever, congenital diseases or hereditary diseases; 6) autoimmune diseases, chronic diseases, failure to thrive and other endocrine system-related diseases; 7) Infant formula containing beneficial antibiotics or probiotics that interfere with the results of the study; 8) Infants diagnosed with rhinitis and asthma by medical institutions; 9) Those who did not sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SCORing Atopic Dermatitis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Infant Dermatitis Quality of Life Questionnaire;Children's Quality of Life Index Questionnaire;Dermatitis Family Impact Questionnaire;Incidence rate of eczema after intervention in infants;Recurrence frequency of eczema;Frequency of eczema recurrence;Duration of eczema;The content of immunological markers in serum;Infant growth indicators;Intestinal microflora structure;Incidence rate of rhinitis;Incidence rate of asthma;Infant defecation;Infant sleep status;Infant crying;Infant breastfeeding; | — |
Countries
China
Contacts
Public ContactYan Chen,Wei Wu
Shaoguan Maternity and Child Health Care Hospital
Outcome results
None listed