Tuberculosis
Conditions
Interventions
LcS intervention group:Drink milk drinks containing 10 billion LcS every day
Control group:Placebo
Sponsors
Medical College Of Qingdao University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 to 75 years, DOTS daily regimen (2HRZE/4HR, H = isoniazid, R = rifampicin, Z = pyrazinamide, E = ethambutol; Intensive treatment for the first two months, consolidation therapy for the next four months) ; 2. All participants will be asked to quit smoking and alcohol during the intervention, and must not take probiotics with foods such as yogurt and beverages; 3. They will be required to take the investigational product daily and comply with questionnaires and blood and stool samples.
Exclusion criteria
Exclusion criteria: 1. Patients with baseline liver dysfunction; 2. Pregnant or lactating women; 3. Hypersensitivity to cow's milk; 4. Tuberculosis outside the lungs; 5. Concurrent diabetes mellitus; 6. Severe kidney, heart, or intestinal disease; 7. With chronic inflammatory or autoimmune diseases or psychiatric disorders; 8. Frequent consumption of probiotics or fermented milk; 9. Taking medications or supplements that may affect the results of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastrointestinal adverse reactions; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intestinal flora;Antimicrobial peptides;NK activity;CD4+/CD8+; | — |
Countries
China
Contacts
Public ContactWang Qiuzhen
Qingdao University
Outcome results
None listed