Primary Aldosteronism
Conditions
Sponsors
Drum Tower Hospital Affiliated to Nanjing University Medical School
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age: 18-75 years old. 2.History of hypertension, DBP = 2.5 mmol/L. 4.Primary Aldosteronis diagnosed by increased aldosterone renin ratio (ARR) > 30 ng/dl: ng/ml/h, and serum aldosterone levels >=15 ng/dl, and confirmed by captopril inhibition test.
Exclusion criteria
Exclusion criteria: 1. Abnormal renal function: serum creatinine >= 2*ULN or eGFR 2.5*ULN, TBIL > 1.5*ULN 3. Cardiac insufficiency, acute myocardial infarction, stroke or other acute cardiovascular events within 6 months; 4. Take spironolactone, guanethidine or reserpine 30 days before enrollment; 5. Known or suspected tumor; Other autoimmune diseases, uncontrolled infectious diseases, serious respiratory, blood and nervous system diseases; 6. There is a pregnancy plan in pregnancy or 3 months before and after treatment. Breast-feeding women; 7. Those who have mental illness, alcohol or drug abuse and cannot cooperate with treatment.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| aldosterone to renin ratio; | — |
Primary
| Measure | Time frame |
|---|---|
| Blood pressure;Serum potassium;Plasma renin activity; | — |
Countries
China
Contacts
Public ContactPing Li
Drum Tower Hospital Affiliated to Nanjing University Medical School
Outcome results
None listed