Premature ovarian failure
Conditions
Interventions
Intervention group:ovarian tissue cryopreservation
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
Female
Age
14 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Age 1.1 ng/mL, AFC>6, for those with good ovarian reserve function, the age limit can be appropriately relaxed. 2. The prognosis of primary disease is good. 3. High risk of premature ovarian failure caused by primary disease and its treatment. 4. Able to tolerate laparoscopic or open ovarian tissue biopsy/resection. 5. It is required to maintain normal sex hormone level and menstruation after radiotherapy and chemotherapy. 6. Patients without HRT contraindication. 7. At least 3 days before radiotherapy or chemotherapy. 8. Informed consent of the patient or his guardian.
Exclusion criteria
Exclusion criteria: 1. Decreased ovarian reserve function with AMH <= 1.1ng/ml or AFC <= 6. 2. Tumor involving ovary or ovarian malignant tumor. 3. Patients with serious basic diseases who cannot accept surgery or have important organ complications that affect the prognosis. 4. Radiotherapy and chemotherapy have been performed at the time of enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| female reproductive endocrine function; | — |
Countries
China
Contacts
Public ContactJiarong Zhang
Zhongshan Hospita, Fudan University
Outcome results
None listed