right to left shunt
Conditions
Interventions
Gold Standard:Transesophageal echocardiogram/transthoracic echocardiogram contrast echocardiography, chest CTA.
Any positive item is considered as having right-to-left reflux
Index test:contrast transcrainal Doppler ultrasound
Sponsors
Department of Ultrasound, West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
16 Years to 55 Years
Inclusion criteria
Inclusion criteria: Patients with clinically suspected right-to-left shunt: a. age: 16-54 years old, b. evidence of cryptogenic stroke or high-risk TIA; C. Migraine with aura; D. Other clinically highly suspected cases of right-to-left shunt; E. RoPE >= 6 points; F. Successfully completed the examination of right to left reflux by transesophageal echocardiography (or transthoracic echocardiographic contrast echocardiography) and the examination of pulmonary arteriovenous fistula by chest CT angiography.
Exclusion criteria
Exclusion criteria: Carotid artery ultrasound or CTA/MRA/DSA clearly have atherosclerotic stenosis or arterial dissection, arteritis and other diseases that lead to stroke; Patients with ventricular septal defect; Patients with severe multiple organ failure; Patients with intellectual impairment and serious hearing impairment; Pregnant women; Patients who cannot accept intravenous injection of activated saline for various reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of microemboli;Positive detection rate; | — |
Countries
China
Contacts
Public ContactChenyun Zhou
Department of Ultrasound, Westchina Hospital, Sichuan University
Outcome results
None listed