Episodic diseases of the nervous system
Conditions
Interventions
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: (1) Age: 18-50 years old, male or female; (2) Comply with the 2018 International Society's Headache Classification Third Edition (ICHD-III) diagnostic criteria for migraine, comply with the International Anti Epilepsy Alliance (ILAE) diagnostic criteria for epilepsy (2014), and control subjects (without migraine or epilepsy); (3) Voluntarily sign a written informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients with severe cardiovascular diseases (severe heart failure, atrial fibrillation, after cardiovascular intervention surgery) and cerebrovascular diseases (stroke, cerebrovascular malformations), central nervous system infections, intracranial space occupying lesions, or brain trauma; (2) Secondary epilepsy; (3) People with metabolic diseases such as diabetes; (4) Patients with severe primary diseases of the liver and renal hematopoietic system or severe liver or renal insufficiency (transaminase exceeding 3 times the upper limit of normal value, total bilirubin and creatinine exceeding 1.5 times the upper limit of normal value, or creatinine clearance rate<45ml/min); (5) Migraine patients or controls who took any medication 1 week before the examination; (6) Planned pregnancy, pregnancy, and lactation women; (7) Participants in other clinical intervention trials; (8) Other situations judged by the researcher to be unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Metabolomics;Proteomics; | — |
Secondary
| Measure | Time frame |
|---|---|
| Exosomes;MRI; | — |
Countries
China
Contacts
Public ContactLei Chen
West China Hospital, Sichuan University
Outcome results
None listed