Effect of intraoperative nitric oxide inhalation on the incidence of acute respiratory distress syndrome during liver transplantation: a single-center randomized controlled double-blind study

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300069607

Enrollment

Unknown

Registered

2023-03-21

Start date

2023-04-01

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute respiratory distress syndrome

Interventions

Nitric oxide group:During liver transplantation, after the circulation in the new liver stage is stable (10 min after the new liver stage), the patient will be given continuous inhalation of nitric ox

Intraoperative air inhalation control group:After the circulation stabilizes during the new liver phase of liver transplantation (10 minutes after the new liver phase), inhale equal volume air and con

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. The patients and their families are informed and willing to participate in the study and sign the informed consent form; 2. Patients undergoing liver allograft in our hospital; 3. Preoperative Child-Pugh score was used to evaluate liver function, and acute physiology and chronic health score were used to evaluate the general condition before and 24 hours after operation. Subjects with score <= 20 were included in the study 4. ASA grade I - III, age 18-75, gender unlimited.

Exclusion criteria

Exclusion criteria: 1. Patients and their families refused to participate in the study; 2. Airway hypersensitivity; Baseline FEV1= III, or left ventricular ejection fraction= 2 mg/dL; 5. Acute liver failure with continuous intracranial pressure>50mmHg or cerebral perfusion pressure<40mmHg; 6. Preoperative acute fulminant liver failure or combined with single or multiple organ failure; 7. Patients with primary liver graft nonfunction and secondary abdominal surgery in the early postoperative period; 8. Patients with iNO contraindications, such as severe left ventricular dysfunction and congenital heart disease involving right-to-left shunt; Patients with methemoglobinemia or genetic sensitivity to methemoglobinemia.

Design outcomes

Primary

Measure	Time frame
Incidence of acute respiratory distress syndrome within 3 days after operation;	—

Secondary

Measure	Time frame
mean arterial pressure;heart rate;Arterial oxygen saturation;Respiratory mechanics index;Lung function indicators;Inflammatory indicators;Operation time;Anesthesia time;Vascular occlusion time;ICU stay time;Ventilator tube time;	—

Countries

China

Contacts

Public ContactYao Weifeng

The Third Affiliated Hospital of Sun Yat-sen University

410682373@qq.com13416179794

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026