rectal cancer
Conditions
Interventions
Gold Standard:HE staining and immunohistochemistry of pathologicaltissues and suspicious lymph nodes of patients after surgery
Index test:The accuracy (sensitivity, specificity) of FAPI-MRI in evaluating lymph node metastasis, mesorectal fascial invasion, extraintestinal vascular invasion, and immune cell infiltration in rect
Sponsors
the First Affiliated Hospital of Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1) 18-79 years old, male or female; 2) Diagnosed with locally advanced rectal cancer (stage II/III) from January 2023 to December 2025, intending to receive neoadjuvant chemoradiotherapy and surgical treatment , accepting long-term follow-up; 3) Pelvic FAPI-PET/MRI scan and other imaging examinations are performed within 14 days before radiotherapy and chemotherapy; 4) Signed the informed consent form;
Exclusion criteria
Exclusion criteria: 1) Patients who have received tumor treatments such as radiotherapy, chemotherapy, immunotherapy, etc. before surgery; 2) The patient has contraindications to surgery or radiotherapy, or refuses treatment; 3) Women who are trying to get pregnant, pregnant and lactating; 4) Patients suffering from claustrophobia or other psychiatric disorders; 5) Patients with other malignant tumors or distant metastases; 6) Other cases in which the investigator deems it inappropriate to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Accuracy of FAPI-PET/MRI for the evaluation of lymph node metastasis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Accuracy of FAPI-PET/MRI for the evaluation of invasion of the mesenteric fascia;Accuracy of FAPI-PET/MRI for the evaluation of invasion of the extramural vasculature;Feasibility of FAPI-PET/MRI for the assessment of immune cell infiltration in tumor tissue; | — |
Countries
China
Contacts
Public ContactZhao Feng
the First Affiliated Hospital of Zhejiang University School of Medicine
Outcome results
None listed