Clinical efficacy study of carbon dioxide laser combined with photodynamic therapy for refractory vocal cord leukoplakia

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300069597

Enrollment

Unknown

Registered

2023-03-21

Start date

2023-03-09

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

vocal cord leukoplakia

Interventions

Control group:CO2 laser

Experimental group:CO2 laser combined with photodynamic therapy

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1) 18 to 80 years of age. 2) Patients with histopathologically confirmed vocal cord leukoplakia. 3) Patients with vocal cord leukoplakia who have failed conservative or surgical treatment.

Exclusion criteria

Exclusion criteria: 1) Pregnant or lactating women. 2) Those with a history of laryngeal radiation therapy 3) Those with a history of cancer of the vocal cords 4) Those with other laryngeal diseases that interfere with treatment or follow-up 5) Patients with a history of respiratory infection within the past two weeks, previous or current tuberculosis infection, or long-term steroid use 6) Severe cardiac, hepatic or renal insufficiency or other contraindications to surgery.

Design outcomes

Primary

Measure	Time frame
recurrence;	—

Secondary

Measure	Time frame
Voice quality;	—

Countries

China

Contacts

Public ContactZhenkun Yu

The Affiliated BenQ Hospital of Nanjing Medical University

Yuzhenkun65@hotmail.com15951879988

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026