alzheimer disease
Conditions
Interventions
mild group:Detection of Netrin-1 protein level
Moderate group:Detection of Netrin-1 protein level
severe group:Detection of Netrin-1 protein level
Healthy control group:N/A
Sponsors
Guangzhou Panyu Health Management Center (Guangzhou Panyu Rehabilitation Hospital)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Meet the diagnosis of AD in the "2018 Chinese Guidelines for the Diagnosis and Treatment of Dementia and Cognitive Impairment (2): Guidelines for the Diagnosis and Treatment of Alzheimer's Disease"; 2. Clinical dementia rating scale (CDR) score >= 1; 3. Mini-Mental State Examination (MMSE) score < 26; 4. Voluntary participation in this study and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Vascular dementia, cognitive dysfunction after stroke; 2. Patients with hematological diseases, major organ dysfunction or severe primary disease; 3. Coagulation dysfunction; 4. With severe infection or systemic infection; 5. Patients with a history of mental illness; 6. Poor compliance during the test period, not worthy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detection of Netrin-1 protein level;App protein; | — |
Secondary
| Measure | Time frame |
|---|---|
| Alzheimer's disease assessment scale, ADAS-Cog;Neuropsychiatric scale, NPI score;Activities of daily living, ADL score;Inflammatory factors (IL-6, CRP, TNF- a) level; | — |
Countries
China
Contacts
Public ContactBingjie He
Guangzhou Panyu Health Management Center (Guangzhou Panyu Rehabilitation Hospital)
Outcome results
None listed