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Multicenter, prospective, randomized controlled study comparing the efficacy of left bundle branch regional pacing and biventricular pacing in patients with heart failure combined with non-left bundle branch block

Multicenter, prospective, randomized controlled study comparing the efficacy of left bundle branch regional pacing and biventricular pacing in patients with heart failure combined with non-left bundle branch block

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300069564
Enrollment
Unknown
Registered
2023-03-21
Start date
2023-03-22
Completion date
Unknown
Last updated
2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart failure

Interventions

LBBAP group:left bundle branch area pacing, LBBAP
Biventricular pacing group:Biventricular pacing

Sponsors

Shanghai Chest Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Referring to the 2021 ESC guidelines, patients in sinus rhythmwith indications for CRT (symptomatic heart failure, LVEF = 130 ms) and whose ECG does not meet typical LBBB (Strauss criteria) on ECG.

Exclusion criteria

Exclusion criteria: 1. Patients with a life expectancy of less than 1 year; 2. Patients with right ventricular mechanical valve; 3. Patients with heart transplant or waiting for heart transplant; 4. Patients with severe liver or kidney dysfunction; 5. Patients who have been enrolled in other clinical studies that may affect the purpose of this study.

Design outcomes

Primary

MeasureTime frame
Left ventricular ejection fraction, LVEF;—

Secondary

MeasureTime frame
Left ventricular end systolic diameter, LVESD;Left ventricular end diastolic diameter, LVEDD;NYHA classification;rehospitalization rate of HF;BNP/NT-proBNP;paced QRSd;—

Countries

China

Contacts

Public ContactLi Ruogu

Shanghai Chest Hospital

13564565961@163.com+86 180 1732 0201

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026