NICU sedation
Conditions
Interventions
Case series:None
Sponsors
General Hospital of the Northern Theater of the People's Liberation Army Chinese People's Liberation Army
Eligibility
Sex/Gender
All
Age
18 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1) Mechanically ventilated patients in NICU and received sedation for 72±24 hours; 2) 18 years old = age <80 years old; 18kg/m2=BMI=30 kg/m2;male or female; 3) Target RASS score -2 to -4; 4) According to GCS score, nursing record sheet and other information, comprehensively judge that the patient has received adequate analgesic treatment; 5) patients treated with ciprofol, propofol, dexmedetomidine or midazolam alone or in combination, and the doses of sedatives administered were recorded; 6) The use of vasoactive drugs during sedation was recorded.
Exclusion criteria
Exclusion criteria: 1) Allergy to conventional sedative and analgesic drugs; 2) Under sedation for more than 3 days before ICU admission; 3) Hypotension and bradycardia on ICU admission; 4) History or evidence of: a) cardiovascular system: New York Heart Association (NYHA) class III, IV heart failure, Adams-stokes syndrome; Acute coronary syndrome (ACS) occurred within the past 6 months; The need for medication for bradycardia and/or a heart rate of =50 beats per minute; Severe arrhythmia such as degree II-III atrioventricular block (excluding patients with pacemaker); Acute and chronic myocarditis; Patients who require vasoactive drugs to maintain normal blood pressure; b) previous history of psychotropic and narcotic drug abuse; A history of alcohol abuse within 3 months; A history of drug use; Long-term use of psychotropic drugs; c) severe hepatic and renal dysfunction (child-pugh grade C can be referred for liver function; Renal function: glomerular filtration rate eGFR=30mL/(min* 1.73m2) [eGFR was calculated using the Modified Diet in Renal Disease (MDRD) formula: eGFR=175× serum creatinine (SCr)-1.234× age-0.179 ×0.79(female)]; Dialysis patients; d) grand mal status, seizures; Craniocerebral injury, intracranial hypertension, cerebral aneurysm; Glasgow coma Scale (GCS)=12 points; SOFA score > 9; Patients with high paraplegia and general paralysis; e) the predicted survival time no more than 72 hours; f) pregnant and lactating women; 5) other conditions for which the patient was judged by the investigator to be ineligible.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypotension;Incidence of bradycardia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Usage of vasoactive drugs;survival rate during NICU;GCS score 3 months after discharge (GCS, Glasgow Coma Scale);GCS score 6 months after discharge (GCS, Glasgow Coma Scale); | — |
Countries
China
Contacts
Public ContactXiong Jian
Outcome results
None listed