Diabetes
Conditions
Interventions
Group normal:no intervention
Group prediabetes with drug treatment:no intervention
Group prediabetes with non-drug treatment:no intervention
Group diabetes:no intervention
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Grouping criteria of normal volunteers: 1. Fasting blood glucose 5.6<mmol/L;and 2. HbA1c <5.7%; and 3. Blood glucose at 2 hours after OGTT test<7.8mmol/L. The grouping criteria for pre-diabetic patients: 1. Fasting blood glucose 5.6-6.9mmol/L;or 2. HbA1c 5.7-6.4%;or 3.Blood glucose at 2 hours after OGTT test 7.8 mmol/L-11.0 mmol/L. The grouping criteria for diabetic patients 1.Fasting blood glucose =7.0mmol/L; or 2.HbA1c=6.5%; or 3.Blood glucose at 2 hours after OGTT test=11.1mmol/L; or 4.Random blood glucose =11.1mmol/L.
Exclusion criteria
Exclusion criteria: 1) Pregnancy status. 2) Uncontrolled hyperthyroidism, hypothyroidism, Cushing's disease and other endocrine diseases that affect glucose metabolism. 3) Uncontrolled rheumatoid arthritis, lupus erythematosus and other immune systemic diseases. 4) Abnormal liver function (ALT and AST are more than 2.5 times the upper limit of normal) or impaired kidney function (serum creatinine) =133umol/ or estimated glomerular rate filtration (eGFR) less than 30mL/min/1.73m2) or other His organs are not fully functioning. 5) Patients with a history of tumor and an estimated survival of less than five years. 6) Severe acute infection, surgery and trauma have occurred recently. 7) Alcohol and drug addicts. 8) Under 18 years old or over 75 years old.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HbA1c; | — |
Secondary
| Measure | Time frame |
|---|---|
| metabonomics;Intestinal flora diversity;lipidomics;proteomics; | — |
Countries
China
Contacts
Public ContactRen Yan\Liao Jiayu \Huang yan
Outcome results
None listed