Hospital-acquired pneumonia/ Ventilator-associated pneumonia
Conditions
Interventions
Group 1:Routine treatment + omadacycline
Group2:Routine treatment + Tegacyclin
Sponsors
Lanzhou University Second Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Meet the diagnostic criteria for HAP/VAP in the above Guidelines for the diagnosis and treatment of hospital-acquired pneumonia and ventilator-associated pneumonia in adults in China (2018 edition); microbiological culture results suggest XDR-resistant bacteria.
Exclusion criteria
Exclusion criteria: (1) those with positive blood cultures; (2) those with cranio-cerebral disease involving the respiratory center and unable to maintain voluntary respiratory rhythm; (3) those with neuromuscular disease causing respiratory muscle weakness; (4) those with bacterial culture results of Pseudomonas aeruginosa, Aspergillus spp. and Providence spp. etc.; (5) those who had used omadacycline and/or tigecycline anti-infection regimens before enrollment; (6) women during pregnancy and lactation; (7) those aged <18 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| survival rate and fatality rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of mechanical ventilation, duration of ICU stay, duration of hospital stay;Recurrence of respiratory failure after deconditioning; | — |
Countries
China
Contacts
Public ContactLi Ma
Second Hospital of Lanzhou University
Outcome results
None listed