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The effect of intravenous lidocaine on the ED50/ED95 of propofol for successful placement of a double-lumen laryngeal mask airway and the incidence of perioperative complications

The effect of intravenous lidocaine on the ED50/ED95 of propofol for successful placement of a double-lumen laryngeal mask airway and the incidence of perioperative complications

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300069522
Enrollment
Unknown
Registered
2023-03-20
Start date
2023-03-20
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing hysteroscopy under general anesthesia with laryngeal mask airway

Interventions

Sponsors

West China Second University Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: The first part of this study (the effect of intravenous lidocaine on the ED50 and ED95 of propofol for successful placement of a double-lumen laryngeal mask airway, and the incidence of perioperative complications in adult patients): patients with ASA physical status I or II, aged 18-60 years, fasted from solid foods up to 6 hours and clear liquids up to 2 hours before surgery were included. The second part of this study (the effect of intravenous lidocaine on the ED50 and ED95 of propofol for successful placement of a double-lumen laryngeal mask airway, and the incidence of perioperative complications in elderly patients):patients with ASA physical status I or II, aged 60-80 years, fasted from solid foods up to 6 hours and clear liquids up to 2 hours before surgery were included.

Exclusion criteria

Exclusion criteria: Exclusion criteria were as follows: patients with body max index(BMI )>28 kg/m2 or BMI<18 kg/m2;patients with body weight < 40 kg; patients with difficult airway, recent history of upper respiratory tract infection and gastroesophageal reflux; patients allergic to local anesthetics, propofol, fentanil or other drugs related to this study; patients with severe liver and kidney dysfunction, endocrine diseases, metabolic diseases, cardiovascular diseases, respiratory system diseases or central nervous system diseases; patients who received sedatives, analgesics, and drugs that may affect the metabolism of local anesthetics for a long time or within 7 days; patients who received other experimental drugs or participated in other clinical trials within 3 months before the study; patients addicted to alcohol or drugs.

Design outcomes

Primary

MeasureTime frame
LMA insertion is invalid or effective;

Secondary

MeasureTime frame
Total amount of propofol induction;Extubation time;hypotension;atropine consumption;

Countries

China

Contacts

Public ContactJuan Ni

West China Second University Hospital

nijuankiki@163.com+8618180609890

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026