Hepatocellular carcinoma
Conditions
Interventions
Operation group:Surgical removal of tumor
Non-operative group:Continue targeted immunotherapy
Sponsors
Eastern Hepatobiliary Surgery Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with unresectable hepatocellular carcinoma before treatment are generally in good condition with an estimated overall survival time of more than 6 months. 2. All patients were successfully transformed by targeted therapy combined with immunotherapy. 3. All patients had primary liver cancer confirmed by MRI or CT, and the imaging data were complete, which could determine the remission time. 4. Preoperative liver function assessment Child-Pugh grade was A or B, and prothrombin time (PT) was less than 4 seconds of normal control. Gastroscopy esophageal vein without severe varicosity, no active digestive tract ulcer. No hepatic encephalopathy or/and moderate or above ascites. Renal function and cardiopulmonary function are basically normal. Hemoglobin =90g/L, white blood cell count =3.0×109/L, neutrophil count =1.5×109/L, platelet count =60×109/L, no definite cachexia; 5. No pregnancy, HIV or syphilis infection, understanding of the study and signed an informed consent.
Exclusion criteria
Exclusion criteria: 1. Distant metastasis of tumor has occurred, such as metastasis of lung, brain, bone, etc 2. Patients who did not meet the requirement of surgical resection after conversion therapy 3. Patients with severe varicose esophagus and gastric fundus veins, tendency of gastrointestinal bleeding, or history of massive gastrointestinal bleeding; 4. Patients with heart, lung and renal insufficiency. Oral administration of warfarin and other anticoagulant drugs within 2 weeks. 5. Researchers believe that participants should not participate in this study for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of remission; | — |
Countries
China
Contacts
Public Contactshuqun Cheng
Eastern Hepatobiliary Surgery Hospital
Outcome results
None listed