Osteoarthritis
Conditions
Interventions
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-80 years, voluntarily sign the ICF approved by the ethics committee before any research procedure begins, and agree to participate in this research; 2. Diagnosed of end-staged osteoarthritis and need to be treated with total joint arthroplasty.
Exclusion criteria
Exclusion criteria: 1. Patients with diabetes or other diseases that lead to elevated blood glucose; 2. Steroid or immunosuppressive drugs used within 6 months before operation; 3. Patients with a history of allergy to glucocorticoids or with adverse reactions to the drugs used in this study; 4. Patients with severe liver and kidney dysfunction; 5. Patients wtith inflammatory diseases, including infectious arthritis, rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, etc.; 6. Patients with contraindications to glucocorticoid use, such as active ulcer, chronic infection, severe osteoporosis, mental disease, hypokalemia, etc.; 7. Patients with joint revision and joint infection; 8. Patients who are allergic to other drugs used in this experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fasting Blood Glucose; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postprandial Blood Glucose;Wound complications;Incision infection;Periprosthetic infection;90 day postoperative readmission rate;Postoperative mortality at 90 days;Adverse reactions associated with dexamethasone; | — |
Countries
China
Contacts
Public ContactZhou Zongke
West China Hospital of Sichuan University
Outcome results
None listed