Mood disorder
Conditions
Interventions
Bifidobacterium longum CCFM687 group:Consume 2 packages of probiotics daily (viable count >= 10^9CFU/ day)
Pediococcus acidilactici CCFM6432 group:Consume 2 packages of probiotics daily (viable count >= 10^9CFU/ day)
Lactobacillus reuteri CCFM1288 group:Consume 2 packages of probiotics daily (viable count >= 10^9CFU/ day)
Sponsors
Wuxi Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Clinical diagnosis of depressive disorder or anxiety disorder; 2. Meet the hospital anxiety and depression scale (HADS) score >= 11; 3. Aged >= 18 years; 4. Primary school education level or above, no speech expression barrier.
Exclusion criteria
Exclusion criteria: 1. Refractory depression; 2. Conform to DSM-IV Axis I diagnosis of other mental diseases; 3. Suicide and self injury; 4. Patients with schizophrenia, bipolar disorder and neurodegenerative diseases; 5. Serious physical diseases, such as HIV, history of epilepsy, history of heart, hyperthyroidism and other serious physical diseases; 6. Pregnant or breast-feeding women; 7. Male or female during pregnancy (childbirth); 8. Have used antibiotics, probiotics and their products in the past month; 9. Unwilling to accept clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hospital Anxiety and Depression Scale;Self-Rating Anxiety Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fecal microbiota analysis;Serological indicators;Gastrointestinal Symptom Rating Scale-self;Pitts? urgh Sleep Quality Index; | — |
Countries
China
Contacts
Public ContactJun Wang
Wuxi Mental Health Center
Outcome results
None listed