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Correlation study of intestinal microflora changes in cirrhotic patients with portal hypertension before and after treatment

Correlation study of intestinal microflora changes in cirrhotic patients with portal hypertension before and after treatment

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300069471
Enrollment
Unknown
Registered
2023-03-17
Start date
2023-03-20
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cirrhotic portal hypertension

Interventions

endoscopic treatment group:N/A
tips treatment group:N/A
control group:none

Sponsors

Shandong Provincial Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-75 years; 2. Presence of cirrhosis; 3. Upper endoscopy confirmed EV or gastric varices; 4. Receive Endoscopic therapy or tips were performed.

Exclusion criteria

Exclusion criteria: 1. Patients with liver cirrhosis and liver cancer confirmed by CT or MRI, histopathology, or other malignant tumors such as gastric cancer and pancreatic cancer confirmed by histopathology; 2. Child Pugh score > 12; 3. Patients with cirrhosis complicated with systemic lupus erythematosus, Crohn's disease, ulcerative colitis and other inflammatory bowel diseases; Patients with cirrhosis and hematological diseases; 4. Severe cardiopulmonary dysfunction; 5. Have a history of drinking alcohol, or use of antibiotics and probiotics in the past month; 6. Suffer from neurological diseases, such as Alzheimer's disease, Parkinson's disease, and non-hepatic metabolic encephalopathy; 7. Use of antipsychotic drugs, such as antidepressants or sedatives; 8. Patients with a history of overt hepatic encephalopathy; 9. Pregnant or lactating women; 10. Patients who were considered by the investigator to be ineligible for inclusion.

Design outcomes

Primary

MeasureTime frame
inflammatory factor;gut microbita;

Countries

China

Contacts

Public ContactChunqing Zhang

Shandong Provincial Hospital

zhangchunqing_sdu@163.com15168886028

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026