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To investigate the clinical application of regenerative gingival replacement biomaterials in the treatment of patients with attached gingival loss

To investigate the clinical application of regenerative gingival replacement biomaterials in the treatment of patients with attached gingival loss - Clinical application of regenerative gingival substitute biomaterials

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300069465
Enrollment
Unknown
Registered
2023-03-17
Start date
2023-03-17
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal diseases

Interventions

Group1:Using AlloDerm SELECT acellular dermal matrix
Group2:Using Geistlich Mucograft Collagen Matrix Membrane

Sponsors

PLA Air Force Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
25 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1. Patients are aged between 25 and 50 years old; 2. The width of attached gingival retraction is greater than or equal to 2 mm; 3. No obvious malocclusion; 4. Patients who can maintain good oral hygiene; 5. No systemic diseases affecting the course of periodontal disease; 6. No abnormal attachment was found in the frenulum; 7. No periodontal operation within 12 months.

Exclusion criteria

Exclusion criteria: 1. The root surface of the tooth can not obtain normal attachment; 2. Root caries that need to be repaired; 3. Heavy smokers (> 10 sticks per day); 4. Systemic diseases affecting the course of periodontal disease [such as diabetes, hypertension, radiotherapy history or cancer treatment history, such as liver, kidney, hematopoietic system and other serious primary diseases, or liver function abnormalities, AST, ALT greater than 1.1/2 times the normal value, creatinine greater than the upper limit of normal value; psychiatric patients; tumor patients, expected life < 6 months; Patients with renal insufficiency (creatinine, urea nitrogen more than 1.2 times the normal range) with a history of immunodeficiency, including HIV positive or other acquired, congenital immunodeficiency diseases, or a history of organ transplantation; 5. Allergic to anesthetics and other drugs; 6. Pregnant or lactating women; 7. Refused to participate in this clinical researcher for various reasons; 8. Partners or first-degree relatives of research center staff or researchers; 9. Other situations in which the researchers considered unsuitable for inclusion.

Design outcomes

Primary

MeasureTime frame
Buccal attached gingival width;Buccal attached gingival thickness;

Secondary

MeasureTime frame
Attached gum color;Attached gingival edema;Patient's pain;

Countries

China

Contacts

Public ContactHui Miao

PLA Air Force Military Medical University

miao84776093@163.com+86 18291875511

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026