Migraine
Conditions
Interventions
Group A:opposing needling
Group B:affected side needling
Group C:Sham opposing needling
Healthy Group:None
Sponsors
The Second Affiliated Hospital of Yunnan University of Chinese Medicine/Yunnan University of Chinese Medicine
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Migraine (1) Right-handed, female, high school or above education, aged 18-45 years old; (2) Patient meets the diagnostic criteria of migraine without aura in the International Classification of Headache Disorders ICHD-3 designated by the International Headache Society (IHS) in 2018; (3) In the past 3 months, the headache attack was >= 2 times per month, and the headache days were < 15 days per month; (4) Moderate headache attacks (VAS score of 3-7) in the last 2 weeks (baseline period); (5) History of migraine for more than 1 year and no history of long-term dysmenorrhea; (6) Not taking painkillers within 1 month; (7) Not having received acupuncture treatment within 1 month; (8) Those who voluntarily participate in this study and sign the written informed consent; (9) No metallic implants in the body and no fMRI contraindications; (10) Not participating in any other trial during the study period; Note: Patients who meet the above 10 items at the same time may be included in this study. 2. Healthy subjects (1) Right-handed, female, high school or above education, aged 18-45 years old; (2) No history of long-term dysmenorrhea, any neurological or psychiatric diseases, or family genetic history; (3) No physical abnormalities (e.g. cold, fever, etc.) during the trial; (4) Not drugs or alcohol use for at least 2 days before enrollment, and no use of any stimulant medication for at least 1 month. (Only if the above 4 criteria are met at the same time can be included)
Exclusion criteria
Exclusion criteria: 1. Migraine Patients matching any of the following criteria will be excluded: (1) Patients with bilateral or alternating unilateral migraine, or with other chronic pain (e.g., dysmenorrhoea, chronic low back pain, etc.); (2) Patients with other types of headaches or headaches of unknown diagnosis; (3) Patients with severe organ or body diseases; (4) Those with severe anxiety, depression, insomnia and other psychiatric disorders; (5) Pregnant and lactating women, or those who have the need to have children within the last year; (6) Patients with definite organic lesions of the brain or significant asymmetry between the right and left side of the skull; (7) Patients with conditions contraindicating MRI (e.g., metallic foreign bodies, vascular stents, pacemakers, dentures, claustrophobia, etc.); (8) Patients who are currently taking analgesics and psychotropic drug dependence; (9) People with special needs such as transgender, homosexual, abnormal sexual orientation, special fetishes, alcohol addiction, etc.; (10) Have participated in a similar study within the last 3 months. 2. Healthy subjects (1) Accompanied by serious diseases of the heart, brain, liver, kidney and other important organs; (2) With mental or physical disabilities; (3) Suspected or true history of alcohol or drug abuse (4) With conditions contraindicating MRI (e.g. metallic foreign bodies, vascular stents, pacemakers, dentures, claustrophobia, etc.); (5) Women are pregnant and lactating. (Any one item is excluded)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Multimodal image data;Visual analogue scale score of headache intensity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Days of headache attacks;Number of headache attacks; | — |
Countries
China
Contacts
Public ContactTaipin Guo
Yunnan University of Chinese Medicine
Outcome results
None listed