mental disease
Conditions
Interventions
207-1 low dose:Bifidobacterium breve 207-110 billion cfu per day for 30 days.
207-1 high dose:Bifidobacterium breve 207-150 billion cfu per day for 30 days.
207-27 low dose:Lactobacillus paracasei 207-2,710 billion cfu per day for 30 days.
207-27 high dose:Lactobacillus paracasei 207-2,750 billion cfu per day for 30 days.
Placebo:Placebo (maltodextrin) was taken per day for 30 days.
Sponsors
Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 30 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-35 year; 2. At least two of the following conditions are met: (1) Self-perceived high mental stress; (2) Obese body size (BMI >= 22); (3) Poor sleep quality; (4) Constipation (< 3 times/week or difficult bowel movement); 3. Willing to take probiotics and cooperate with stool collection, questionnaire and physical examination.
Exclusion criteria
Exclusion criteria: 1. Those who have recently taken antibiotics, probiotics, prebiotics, etc. that affect the test results (yogurt does not count among them); 2. Those with organic diseases, such as heart disease, liver cirrhosis, etc.; 3. Those who have mental disorders; 4. Diagnosed by hospitals at or above the county level with chronic non-communicable diseases, such as hypertension, gout, diabetes, etc.; 5. Patients diagnosed by hospitals at or above the county level with allergic diseases such as drug allergy, food allergy, rhinitis, etc., or those with a history of allergic diseases; 6. Have a history of gastrointestinal surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut Microbiota;Short-chain fatty acids;neurotransmitter;HPA axis hormone;pittsburgh sleep quality index, PSQI;IL-6;IL-10;IL-12;IL-1ß;TNF-a; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine;Urine routine;Liver function and renal function; | — |
Countries
China
Contacts
Public ContactFang He
Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University
Outcome results
None listed