Postoperative delirium
Conditions
Interventions
Remimazolam group:Use remimazolam besylate during anesthesia maintanence
Propofol group:Use protocol during anesthesia maintanence
Sponsors
Dalian Municipal Friendship Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients aged >= 65 years with elective unilateral total hip replacement surgery; 2. Preoperative FRAIL Frailty Scale score 3-5 points; 3. Body mass index (BMI) 18-30 kg/m2; 4. There are no serious heart, lung, brain and other important organ lesions, and there are no obvious abnormalities in liver and kidney function; 5. The same group of physicians complete the operation; 6. Have a clear understanding of the study before surgery and voluntarily participate in it, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Allergy to anesthetic drugs; 2. Those with severe cognitive impairment before surgery, <= 17 points of illiteracy on the Mini-Mental State Examination (MMSE) scale, <= 20 points of primary school, <= 22 points of secondary school, and <= 23 points of university degree or above; 3. Inability to conduct follow-up assessments; 4. Patients with a history of long-term use of psychotropic substances and drug abuse, and alcohol abuse within 2 years before the screening stage; 5. the use of benzodiazepines and opioids for nearly three months; 6. inability to communicate with patients (speech impairment or severe hearing impairment); 7. After surgery, enter the ICU for treatment of patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| FRAIL scale score;Dosage of remimazolam or propofol;Dosage of remifentanil;Awakening time;MMSE score;VAS score;Incidence of postoperative nausea and vomiting;Subtype of delirium; | — |
Countries
China
Contacts
Public ContactTu Xiaokang
Dalian Municipal Friendship Hospital
Outcome results
None listed