Septic Shock
Conditions
Interventions
Placebo Control Group:5% Glucose Intravenous Injection and Standard Treatment
Sponsors
General Hospital of Southern Theatre Command
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 years and over; 2. Diagnosed as septic shock based on of Sepsis-3 definition from the international consensus published in 2021. This definition includes suspected or confirmed infections, an increase in Sequential Organ Failure Assessment (SOFA) score by 2 or more points, the need for vasopressor therapy due to hypotension, and a lactate level greater than 2 mmol/L; 3. Conformed to refractory septic shock, which is defined in this trial as septic shock requiring a continuous infusion of norepinephrine greater than 0.5 ug/kg/min or an equivalent dose of other vasopressors to maintain mean arterial pressure (MAP) greater than 65 mmHg; 4. Initially diagnosed as refractory septic shock in research hospitals.
Exclusion criteria
Exclusion criteria: 1. Patients in pregnancy or lactation; 2. Allergic to methylene blue; 3. With glucose-6-phosphate-dehydrogenase deficiency; 4. With terminal malignant cancer; 5. With non-infectious risk factors leading to death such as uncontrollable hemorrhea, brain hernia; 6. With irreversible disease or in terminal stage; 7. Refusing active treatment or planning to leave ICUs within 48 hours; 8. Enrolled in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total dose of vasopressors; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood Pressure;Heart Rate;Hemodynamic indexes;Oxygen metabolism indexes;Tissue perfusion indexes;Major organ function indexes;Plasma cytokines and other factors; | — |
Countries
China
Contacts
Public ContactZhifeng Liu
General Hospital of Southern Theatre Command of People's Liberation Army
Outcome results
None listed