sepsis
Conditions
Interventions
non-sepsis:none
Sponsors
The Third Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Patient aged >= 18 years; 2. Less than 24 h after admission; 3. Meeting the diagnostic criteria for sepsis (clear focus of infection; SOFA score >= 2 points): Determination of infection focus: respiratory tract infection, urinary tract infection, intestinal infection and other clear infection focus, except central nervous system infection focus; 4. Non-sepsis patients: patients with infection sites, such as skin, digestive tract, urinary tract, etc., but did not meet the diagnostic criteria for sepsis; 5. Informed consent of patients and their families to participate in the research project; 6. Able to communicate with researchers briefly and complete the assessment of relevant scales.
Exclusion criteria
Exclusion criteria: 1. Patients with primary central nervous system diseases (such as cerebral hemorrhage, cerebral infarction, cerebral trauma, etc.); 2. The patient has a pre-existing psychiatric or neurological condition (e.g., intracranial tumor); 3. Clear evidence of encephalitis/meningitis; 4. Disorders of consciousness and changes of mental state caused by acute encephalopathy caused by other reasons. Including metabolic encephalopathy, blood electrolyte disorder, toxic encephalopathy, central nervous system primary disease, and sedative sleep drug interference; 5. Antibiotics, hormones and other immunosuppressive drugs were used before admission; 6. Renal replacement therapy such as hemofiltration and hemodialysis; 7. Tumor, autoimmune disease, cirrhosis, uremia, etc.; 8. Recent history of blood transfusion; 9. Patients or family members refused to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sofa scale, Sequential Organ Failure Assessment;GCS, Glasgow Coma Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mechanical ventilation time;Length of ICU stay;Leukocyte Count; | — |
Countries
China
Contacts
Public ContactLi Gong
The Third Xiangya Hospital of Central South University
Outcome results
None listed