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Effect and mechanism of menstrual adjustment and pregnancy-promoting needle on IVF-ET pregnancy outcome in POR patients based on Nrf2/ART antioxidant pathway: a multicenter randomized controlled study

Effect and mechanism of menstrual adjustment and pregnancy-promoting needle on IVF-ET pregnancy outcome in POR patients based on Nrf2/ART antioxidant pathway: a multicenter randomized controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300069406
Enrollment
Unknown
Registered
2023-03-15
Start date
2023-03-20
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

poor ovarian response

Interventions

Observation group:GnRH-ant scheme and acupuncture treatment
Control group:GnRH-ant scheme

Sponsors

Shandong Provincial Third Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
25 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Aged 25-45 years; 2. Meet the 3 groups and 4 groups of POR Poseidon classification standards; 3. Indications for antagonist regimens; 4. Informed consent, sign informed consent form; 5. No acupuncture treatment has been performed in the past 2 months.

Exclusion criteria

Exclusion criteria: 1. Related diseases that affect the outcome of IVF-ET pregnancy, such as untreated hydrosalpinx, uterine fibroids >= 4 cm, severe adenomyosis, stage III or IV endometriosis, untreated endometrial lesions, etc.; 2. The male suffers from malformation, weak sperm and oligospermia; 3. Patients who are conducting other drug research.

Design outcomes

Primary

MeasureTime frame
The total number of ovums obtained;

Secondary

MeasureTime frame
Nrf2 protein content and gene expression;

Countries

China

Contacts

Public ContactBai Tianyu

The Third Hospital of Shandong Province

283799804@qq.com+86 15168879181

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026