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Mechanisms of cortical plasticity and prediction of efficacy in the treatment of depression with the sustained burst model (cTBS)

Mechanisms of cortical plasticity and prediction of efficacy in the treatment of depression with the sustained burst model (cTBS)

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300069392
Enrollment
Unknown
Registered
2023-03-15
Start date
2023-03-15
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression

Interventions

cTBS group:cTBS intervention
Sham cTBS group:Sham cTBS intervention
Control group:No

Sponsors

Ningbo Kangning Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Met the diagnostic criteria for depression in the International Classification of Diseases, 10th Revision (ICD-10); 2. Were right-handed; 3. Were aged 18-65 years and of either sex; 4. Were willing to participate in the study and signed an informed consent form.

Exclusion criteria

Exclusion criteria: 1. Patients with severe physical diseases, infectious diseases and immune system diseases; 2. Patients with severe neurological diseases, mental retardation or brain organic diseases; 3. Pregnant or breastfeeding women; 4. Receiving electricity within the past 3 months Shock therapy; 5. Have a history of electra convulsive therapy; 6. Those who are not suitable for rTMS or tDCS treatment after evaluation, and who cannot complete the collection of related indicators.

Design outcomes

Primary

MeasureTime frame
HAMD (Hamilton Depression Rating Scale) score;HAMA (Hamilton Rating Scale Anxiety) score;PSQI (Pittsburgh Sleep Quality Index) score;Clinical Global Impression (CGI);TMS-EEG (Transcranial Magnetic Stimulation Electroencephalogram);fNlRs (Functional Near-Infrared Spectroscopy);rs-EEG (resting-state Electroencephalogram);ERP (Event Related Potentials);

Countries

China

Contacts

Public ContactZhiwang Liu

Ningbo Kangning Hospital

44973443@qq.com+86 137 8001 0463

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026