The pathogenesis and intervention cohort study of depression

Study on the pathogenesis and intervention techniques of depression

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300069372

Enrollment

Unknown

Registered

2023-03-14

Start date

2023-04-01

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

major depressive disorder

Interventions

Depression group:Marketed drug

healthy control group:None

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Depression group Currently meeting the diagnostic criteria of major depressive disorder in DSM-V. Age between 18 and 60 years. No medication, first episode; Voluntary to participate in this study,understand the research content and sign the informed consent. 2. Healthy control Group No current or past mental disorder meeting any of the DSM-V diagnostic criteria; Age between 18 and 60 years. Obtaining written informed consent from the patient and legal guardian.

Exclusion criteria

Exclusion criteria: 1. Depression group Neurological diseases; Brain organic mental disorders and mental disorders caused by physical diseases; Other mental disorders that meet the diagnostic criteria of DSM-V, such as IQ <= 70 or mental retardation or other neurodevelopmental disorders; Use, abuse/dependence of psychoactive substances other than alcohol and tobacco; Present with significant active physical disease; Pregnant and lactating women. 2. Healthy control Group Family history of mental disorders in two generations; Neurological diseases; Taking benzodiazepines within 6 months; Present with significant active physical disease; Unable to complete relevant testing; Pregnancy and nursing women.

Design outcomes

Primary

Measure	Time frame
Beck Depression Inventory, BDI;Snaith-Hamilton Pleasure Scale, SHAPS;Beck Anxiety Inventory, BAI;Temporal Experience of Pleasure Scale, TEPS;Pittsburgh sleep quality index, PSQI;Morningness-Eveningness Questionaire;The Epworth Sleeping Scale, ESS ;Connor-Davidson resilience scale, CD-RISC;Social support rating scale, SSRS;Eysenck Personality Questionnaire, EPQ-88;Life Events Scale, LES;Adolescent Self-Rating Life Events Check List, ASLEC;Dimensional Anhedonia Rating Scale, DARS;The Cambridge Neuropsychological Automated Test Battery;17-item Hamilton Depression Scale (HAMD-17);the 14-item Hamilton Rating Scale for Anxiety (HAMA-14);Global Assessment Scale, GAS;Insight and Treatment Attitude Questionnaire, ITAQ;Social Disability Screening Schedule, SDSS;Childhood Trauma Questionnaire, CTQ;Ottawa Self-injury Inventory;	—

Measure

Time frame

Beck Depression Inventory, BDI;Snaith-Hamilton Pleasure Scale, SHAPS;Beck Anxiety Inventory, BAI;Temporal Experience of Pleasure Scale, TEPS;Pittsburgh sleep quality index, PSQI;Morningness-Eveningness Questionaire;The Epworth Sleeping Scale, ESS ;Connor-Davidson resilience scale, CD-RISC;Social support rating scale, SSRS;Eysenck Personality Questionnaire, EPQ-88;Life Events Scale, LES;Adolescent Self-Rating Life Events Check List, ASLEC;Dimensional Anhedonia Rating Scale, DARS;The Cambridge Neuropsychological Automated Test Battery;17-item Hamilton Depression Scale (HAMD-17);the 14-item Hamilton Rating Scale for Anxiety (HAMA-14);Global Assessment Scale, GAS;Insight and Treatment Attitude Questionnaire, ITAQ;Social Disability Screening Schedule, SDSS;Childhood Trauma Questionnaire, CTQ;Ottawa Self-injury Inventory;

—

Secondary

Measure	Time frame
trypophobia questionnaire;Migraine questionnaire;pattern glare test;	—

Countries

China

Contacts

Public ContactXiaohong Ma

West China Hospital of Sichuan University

maxiaohong@scu.edu.cn+86 189 8060 2101

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026