Postoperative cognitive dysfunction
Conditions
Interventions
Sponsors
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years; 2. Patients who plan to receive elective abdominal surgery and the operation is expected to last more than two hours, hospital stay after operation is greater than or equal to five days; 3. Patients who plan to receive general anesthesia.
Exclusion criteria
Exclusion criteria: 1. The score of preoperative MMSE is less than or equal to 23 points; 2. Severe organ failure (such as heart failure,hepatic failure or kidney); 3. Neurovascular disease with obvious neurological, psychiatric or clinical manifestations or preoperative cognitive dysfunction; 4. Sedatives, psychotropic drugs or hormones are being used; 5. Alcohol and drug abuse; 6. Illiteracy, color blindness, barriers to reading, listening, writing and communication, leading to difficulties in follow-up or poor compliance; 7. Poorly controlled hypertension, diabetes or autoimmune diseases; 8. Patients who have been selected into this study before; 9. The researcher judged that the follow-up visit could not be accepted.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| neurocognitive function; | — |
Secondary
| Measure | Time frame |
|---|---|
| the concentration of transthyretin;the concentration of Aß;the concentration of Retinoic acid;the concentration of Retinol;Metabonomics; | — |
Countries
China
Contacts
Public ContactCao Lin
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Outcome results
None listed