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Novel Optical Coherence Tomography Imaging Biomarkers for High Myopia in Children and Adults to Assess Visual Damage Severity

Novel Optical Coherence Tomography Imaging Biomarkers for High Myopia in Children and Adults to Assess Visual Damage Severity

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300069358
Enrollment
Unknown
Registered
2023-03-14
Start date
2023-04-01
Completion date
Unknown
Last updated
2025-08-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myopia

Interventions

High myopia children - Ophthalmic examinations and questionnaires:N/A
Normal children - Ophthalmic examinations and questionnaires:N/A
High myopia adults - Ophthalmic examinations and questionnaires:N/A
Normal adults - Ophthalmic examinations and questionnaires:N/A

Sponsors

The Chinese University of Hong Kong
Lead Sponsor

Eligibility

Sex/Gender
All
Age
4 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria of High Myopia: Spherical equivalent = 26.0mm. Inclusion Criteria of Control Subjects: 1. Spherical equivalent > -0.50 D; 2. Age and gender-matched with myopia group; 3. No family or personal history of glaucoma or other ocular diseases.

Exclusion criteria

Exclusion criteria: 1. Secondary myopia; 2. LASIK surgery history; 3. History of autoimmunity disease; 4. Severe health problems precluding follow-up; 5. Ocular media opacity; 6. Plan to move from the area within the next 10 years.

Design outcomes

Primary

MeasureTime frame
Difference of choroidal and retinal vasculature (CVI, FAZ area, FAZ circularity, VD, VDI and FD) for myopia progression between high myopia and normal children;Difference of choroidal and retinal vasculature (CVI, FAZ area, FAZ circularity, VD, VDI and FD) between adults with and without high myopia;

Secondary

MeasureTime frame
Difference of choroidal and retinal vasculature (CVI, FAZ area, FAZ circularity, VD, VDI and FD) between high myopia and normal children at baseline;Difference of choroidal and retinal vasculature (CVI, FAZ area, FAZ circularity, VD, VDI and FD) between adults with and without high myopia at baseline;Difference of choroidal and retinal vasculature (CVI, FAZ area, FAZ circularity, VD, VDI and FD) in adults with different severity of high myopia;

Countries

China

Contacts

Public ContactProf CHEN Lijia Guy

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong

lijia_chen@cuhk.edu.hk+852 3943 5810

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026