psychological stress,postoperative pain
Conditions
Interventions
Test group (K group):Before induction of general anesthesia, 0.5mg/kg dextamine was diluted to 10mL with normal saline and injected intravenously, followed by routine anesthesia induction.
Control group (group C):routine anesthesia induction regimen
Sponsors
Nanjing Drum Tower Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Subjects with single traumatic lower limb fracture undergoing traumatic orthopedic surgery under tracheal intubation under general anesthesia; 2. Age 18-64 years old, male or female; 3. ASA I-III level; 4. Voluntarily joined and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Subjects who are intolerant or allergic to dexketamine, propofol, opioids, dexmedetomidine and other general anesthesia drugs; 2. Used anesthesia within 24 hours before the first operation Subjects who took sexual analgesics; subjects who took long-term (continuous or intermittent) benzodiazepine sleeping pills, hormones, psychotropic drugs, and opioid analgesics; 3. Had a history of drug abuse and/or Subjects with a history of alcohol abuse; 4. Severe cardiovascular diseases (such as myocardial ischemia, angina pectoris, heart failure, and arrhythmia); or subjects with myocardial infarction within the last 6 months; 5. Preoperative Hypertensive subjects with unsatisfactory blood pressure control (systolic blood pressure >= 180mmHg and/or diastolic blood pressure >= 100mmHg); 6. Subjects with decompensated shock; 7. Combined with internal organ damage (hepatic and spleen rupture, etc.) subjects; 8. Subjects with craniocerebral injury, possible intracranial hypertension, cerebral aneurysm, cerebrovascular accident history and central nervous system diseases; 9. Subjects with mental illness (mental disease) before operation schizophrenia, mania, depression, etc.) and subjects with cognitive impairment; 10. Pregnant or lactating female subjects; 11. Subjects with hyperthyroidism; 12. Intraocular Subjects with elevated pressure (such as glaucoma) or combined ocular trauma; 13. Subjects who were judged to be difficult airway before operation (modified McMurley score was grade IV); 14. Subjects within the past 3 months who have participated in drug clinical trials as subjects.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post Traumatic Stress Disorder Self-Rating Scale Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| mean arterial pressure;heart rate;pulse oxygen saturation;stroke volume variation;pulse pressure variation;Systolic pressure;Diastolic pressure;Other hemodynamic parameters;date of surgery;Surgery and Duration of Anesthesia;blood pressure;temperature;blood sugar;age;Body Mass Index;American Society of Anesthesiologists grade;Surgical Apgar score;liquid intake and output volume;bispectral index;blood gas analysis;Pittsburgh sleep quality index;Self-rating depression scale;Self-Rating Anxiety Scale;Trauma Screening Question-naire;VAS pain assessment scale;8-concise quality of life scale;Stress response questionnaire;Other sleep and mood assessments;Midazolam;1% propofol;Vecuronium bromide;Fentanyl;Etomidate;Dextral ketamine;Sevoflurane;Dexamethasone;Dizoxin;Dexmetomidine;Remifentanil;Cis atracurium;2% propofol;Ephedrine;Dopamine;Norepinephrine;Norepinephrine;Uladeur;Nicardipine;Isoproterenol;other Vasoactive drug;Postoperative complication;Postoperative 30-day mortality;Postoperative ICU stay time;Postoperative hospital stay;Whether or not to be admitted to the hospital again and its reasons;Transfer after discharge from hospital; | — |
Countries
China
Contacts
Public ContactZhengliang Ma
Nanjing Drum Tower Hospital
Outcome results
None listed